I could live with either, but if I picked C1 I would have to get a full featured DAM to go with it. Sometimes I prefer C1 and other times Lightroom. I've always kept two raw processors, having started in the day when none of them would do justice to all images. If I have a lot of images to review I will use FastRawViewer to cull my shots before the import to Lightroom. Even with a very fast machine and GPU you have time to go grab a snack before you can review your images using Lightroom. One of the big differences is in how long it takes after import to be able to review and cull shots. Indoors in mixed lighting the color shifts (due to different lighting color temperatures) are less in C1. Outdoor shots in full sun have much more contrast in Lightroom and I have to apply a custom curve to get them to match what I saw at the time I took them. Lightroom and C1 each give me a different starting point after import. While it might make more sense to run C1 in Sessions mode (and avoid the second import) I prefer to not have the C1 session files intermixed with the images when I do backups. My Leica images are almost always processed in C1. After import into Lightroom I either process in Lightroom, or do a second import into my C1 catalog. Phase One's Media Pro is much better, but still doesn't do it for me. (The images are not contained in the catalog, just the references to their folder location.) The C1 catalog is not nearly as full featured and does not do many of the functions I use in Lightroom's catalog. So all my work gets ingested into Lightroom. I really depend on the Lightroom catalog, which now supports 100K of my images. Lightroom has a very nice automated tool for perspective distortion, while C1's is manual in operation. I use Structure a lot, particularly with Monochrom images. No Dehaze tool in C1 and no Structure Tool in Lightroom. The tools sets are generally comparable, but there are differences. If you are comfortable with Photoshop many of the C1 tools work like their counterparts in Photoshop. I have always liked C1 color better than ACR and Lightroom, but that gap has closed considerably and now with Lightroom 7.3 I could be satisfied with the output from either one. I'm an M system shooter, but have been using Capture One since version 3.7 and Lightroom since the beta that preceded version 1.
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Mission San Juan Capistrano, historic landmark and museum, is the Birthplace of Orange County. Sit back, relax, and enjoy the beauty and charm of Dana Point Harbor.Įxperience a VIP guided tour and explore the San Juan Capistrano Mission Grounds. Additionally, guests may enjoy a fully operative cash bar onboard to delight in a variety of beverages. Our 63-ft Ocean Adventure catamaran features a 360-degree view from its spacious deck. This cruise features a wine host who explains all the wines you will be sampling from The Organic Cellar, which promotes organically grown and pesticide-free wines as well as a sample platter of cheese, crackers, dried fruits, and nuts that pairs with the wines. Join us for an evening cruise aboard our luxury catamaran. Accompanied by naturalists, you will learn about kelp forest ecology and the local history of Dana Point on a 3 - 5 mile round trip hike. Investigate the local foliage and wildlife of the Dana Point Headlands and learn how they have adapted to life on the ever-changing coast. Length of excursion depends on the hike option chosen. Whether it be a calming stroll, or an intense physical workout, this is a great activity to learn about our Chaparral ecosystems and the history of the Laguna Beach area. Each hike presents a variety of local plants and knowledge of the natives who cared for these lands in the past. There are three available options for this hike including easy, moderate, and hard. Discover two options, from a Hike/Snorkeling excursion where you will explore some of our fascinating tide pool organisms along the way, to a snorkeling excursion where we will dive straight into the underwater world of Laguna Beach, and observe the various organisms held in our local kelp forest ecosystems.Įxplore native plants and wildlife along a mountainous ridge overlooking the Laguna Beach coastline. Join our expert naturalists as they lead you to amazing viewpoints and local hidden gems, while pointing out the local history, flora, and fauna.Įxplore the underwater kingdom of life that exists here in Dana Point or Laguna Beach as expert naturalists will guide and find the amazing sea creatures that thrive in our coastal waters. Take off directly from the resort and explore the coastal town’s bike paths and beautiful scenery with the comfort of Electric bicycles assisting with those uphill sections. Zip around on our private custom guided E-bike Tour. Includes complimentary Tennis Racquet and/or Pickleball paddle rentals and water bottles for one hour. Join us for an introduction to Tennis or Pickleball basics and/or to improve your strokes while playing fun games with our in-house Tennis Pro. All abilities welcome! The focus can be tailored to your own ability level and needs. Guests will also be able to enjoy our local dolphin inhabitants frolicking in the Southern California waters.Įnjoy a private Tennis or Pickleball lesson or a group clinic for 2 or more guests. Graceful humpback whales and nurturing gray whales are visible as they travel along our coastline. Dana Point is believed to serve as a visual landmark for several species of whales that migrate along the Pacific Coast. Discover a catalogue of the elevated experiences The Ritz-Carlton, Laguna Niguel offers and reserve your next event.Įmbrace your sea legs on a whale watching excursion and see first-hand why Dana Point is the Dolphin and Whale Watching Capital of the World. From corporate retreats to team bonding excursions, the perfect venue for your next group experience is right along the Pacific Coast. The program enables pathways for undergraduate and graduate students to work jointly with NREL scientists and UConn faculty. Ellen Morris, director of University Partnerships at NREL.Īmong the many goals of the partnership, UConn and NREL will work together to invest in the development of joint solutions to clean energy challenges in the Northeast and increase funding opportunities not otherwise available to either individual institution. “NREL sees the partnership with UConn as a critical part of achieving clean energy at scale that brings together talent from both institutions to further our collective goals,” says Dr. Through its University Partnership Program, NREL works across disciplines to enhance research, foster an exchange of ideas, mobilize resources and create opportunities for undergraduate and graduate students in cutting-edge fields related to the clean energy economy. It joins MIT, Princeton, Georgia Tech, and Carnegie Mellon, to name a few, in the eastern half of the country. UConn is now a member of a prestigious cohort of universities engaged with NREL through its University Partnerships Program. Based in Golden, Colo., NREL has a vast network of industry, academic and government partners throughout the world. NREL is one of 17 DOE national laboratories uniquely focused on creating a clean energy future. “I am proud that UConn is playing an important role in this crucial sector, and I am excited to see the creativity and determination our faculty and students bring to this work.” Inesses and governments respond to the energy challenges of the 21st century,” Maric says. “As one of only five research universities to collaborate with NREL in the eastern United States, we are in a select group of leading institutions whose work will shape the way bus UConn is the fifth university on the East Coast to partner with NREL for clean energy research and innovation. A great deal of related education, research, training, and demonstration related to fuel cells, hydrogen, and batteries happened and continues to happen at UConn. “Connecticut is known as the birthplace of the fuel cells that provided electricity to the command module in the Apollo moon mission. “The partnership between UConn and NREL further builds our university’s reputation as a leader in the field of clean energy research and innovation,” says UConn President Radenka Maric. NREL will establish a research collaboration with UConn at the Innovation Partnership Building (IPB) at the UConn Tech Park designed to leverage scientific knowledge and state-of-the-art facilities to address global energy challenges, including energy efficiency and resiliency, renewable energy technologies, and smart grid innovation. Department of Energy’s (DOE’s) National Renewable Energy Laboratory (NREL) on a collaboration for clean energy innovation and grid resilience. UConn has reached a partnering agreement with the U.S. 7/2/2023 0 Comments Australia lockdown truckersafter allowing both sons to move to Hawaii with ex Kevin FederlineĦ00-million-year-old sacred icons, tropical wonders and Australia's LARGEST National Park: Why the Northern Territory is becoming Australia's must-see destination 'Drama already, let's go!' Love Island fans rejoice as the series gets off to a fiery start as Ella admits she already knows one of the boysīritney Spears shares a throwback snap of her first-born son Sean Preston calling him 'My first love'. weeks after her split from Sir Philip Green's son Brandon Holly Hagan gives birth! Geordie Shore star welcomes a baby boy with husband Jacob Blythe and admits she 'couldn't have wished for a better experience'Įmma Watson's mystery man is finally named as American businessman Ryan Walsh. Kitts! From authentic gourmet experiences to the scenic 'Sugar Train' and the iconic Brimstone Hill Fortress National Park, discover why this Caribbean island is so much more than its beautiful beaches 'The most amazing milestone to experience': Laura Dern celebrates daughter Jaya's graduation from high school after reuniting with ex Ben Harper for ceremony Kylie Jenner highlights her stunningly taut tummy and slimmed-down figure in a tiny bandeau as she prepares for warmer weather: 'Need summer now' New York's most eligible bachelorette Emily Ratajkowski showcases her bombshell figure in skimpy bralette and sheer skirt for night out with pals after buying $60M home with Ben Affleckįrom DMs to down the aisle: Young bride and groom-to-be share their love story and the journey to finding the PERFECT engagement ringĬara Delevingne is ready for business in a jet-black jacket and leather pants while working on New York City set of American Horror Story: Delicate Jennifer Lopez rocks denim Valentino dress with VERY daring side slits as she goes furniture shopping. Madonna shares a brief clip of her new Sam Smith collaboration Vulgar as she dances in a black bodysuit and sizzling fishnets Glee actress Jane Lynch weighs in on Phillip Schofield affair controversy as Holly Willoughby issues statement after her return to This Morning Last month, a convoy of trucks drove through Sydney, blocking traffic and blaring their horns, to protest against the temporary closure of construction sites.ĭaily Mail Australia has contacted SA Police, WA Police, and QLD Police for comment. If the protest proceeds as planned, it will not be the first time truck drivers blocked roads to rally against Covid lockdowns. More than 2000 people also gathered in Brisbane City Botanic Gardens and Adelaide's Rundle Park to rally against the lockdown and vaccine measures. The constable was taken to hospital for head and neck injuries. Police said a 32-year-old man who allegedly assaulted an officer was arrested and charges are expected to be laid. They issued 137 tickets after stopping around 38,000 cars approaching the city. In NSW, police arrested 47 people and fined more than 260 in relation to protests across the state. Six police officers were hospitalised and three people remain in custody for allegedly assaulting police, with officers using pepper spray on multiple people to quell the crowd. Victorian police arrested 218 people and issued 236 fines, each worth $5452, for health order breaches. News of the walkout comes as thousands of anti-lockdown protesters hit the streets of capital cities on Saturday as highly infectious Delta outbreaks in Melbourne and Sydney spiral out of control.Ī 4000-strong crowd of mostly unmasked protesters letting off flares, yelling slogans and blasting music moved through Melbourne's CBD on Saturday afternoon. 'Victoria Police will respond to ensure community safety and compliance of the CHO directions,' they said.Ī GoFundMe page has been launched to financially support truck drivers as they strike Victoria Police spokesperson said the force is also aware of the planned demonstration. 'NSW Police will continue to conduct Operation STAY AT HOME to ensure compliance with the public health orders,' they said. 'Support the men and women who make this country go around, and will be our voice.'Ī NSW Police spokesperson said the force is aware of the planned protest. 'Enough is enough, Australia has had enough and we say no more!' the fundraiser page reads. Those involved are now calling for donations to support Australian truck drivers, with the GoFundMe so far raising $3302 of the $200,000 goal in five hours. Other videos from truck drivers overseas have since been posted online, offering Aussie freight transporters advice on how to impede authorities efforts to tow away their vehicles. Truck drivers are reportedly planning to 'block every highway entering into every state' from 9am on Tuesday They launched a site called Have I Been Trained, which lets artists search to see whether their work is among the 5.8 billion images in the data set that was used to train Stable Diffusion and Midjourney. LAION did not immediately respond to a request for comment.īerlin-based artists Holly Herndon and Mat Dryhurst are working on tools to help artists opt out of being in training data sets. Mason encourages any artists who don’t want their works in the data set to contact LAION, which is an independent entity from the startup. The group is in its early days of mobilization, which could involve pushing for new policies or regulation. “There is a coalition growing within artist industries to figure out how to tackle or mitigate this,” says Ortiz. But it’s also a lot more personal, Ortiz says, arguing that because art is so closely linked to a person, it could raise data protection and privacy problems. Karla Ortiz, an illustrator based in San Francisco who found her work in Stable Diffusion’s data set, has been raising awareness about the issues around AI art and copyright.Īrtists say they risk losing income as people start using AI-generated images based on copyrighted material for commercial purposes. Other artists besides Rutkowski have been surprised by the apparent popularity of their work in text-to-image generators-and some are now fighting back. Some artists may have been harmed in the process Stability.AI released the model into the wild for free and allows anyone to use it for commercial or noncommercial purposes, although Tom Mason, the chief technology officer of Stability.AI, says Stable Diffusion’s license agreement explicitly bans people from using the model or its derivatives in a way that breaks any laws or regulations. 7/1/2023 0 Comments Thomas raskin amherstHis mother, Sarah Bloom Raskin, is a graduate of Harvard Law School and a former U.S. 6, 2021 riot at the Capitol, will join U.S. He was a vegan and a supporter of animal welfare. He served as co-director of the BLISS academic tutoring. Jamie Raskin, the Maryland Democrat who led the second impeachment trial of former President Donald Trump after the Jan. He was an Amherst College graduate who interned at the Cato Institute and J Street. Raskin’s father is serving his second term representing Maryland’s 8th congressional district and formerly taught constitutional law at American University. Tommy Raskin is the first-prize winner of the 2012 Humanist Essay Contest for high school students. He was also a second-year law student at Harvard Law School. Also he graduated with a history major and was a member of the Amherst Political Union. “The family is grateful for the outpouring of support and love from neighbors, constituents, and friends but asks everyone to observe strict COVID-19 protocols during this time of grief.” Thomas received his Amherst College diploma in 2017. “Tommy is survived by his beloved sisters Hannah and Tabitha, dozens of loving aunts, uncles, cousins, friends and grandparents Arlene Bloom and Lynn Raskin,” the official statement added. He had been a teaching fellow in the undergraduate course General Education 1171: “Justice: Ethics in an Age of Pandemic and Racial Reckoning,” according to his LinkedIn profile. Thomas Raskin, 25, graduated from Amherst College in 2017. The family did not announce a cause of death. “We are devastated and demolished to be without him.” He had been a teaching fellow in the undergraduate course General Education 1171: Justice: Ethics in an Age of Pandemic and Racial Reckoning, according to his LinkedIn profile. Contact Us (413) 542-2000 Contact Us Map & Directions. Thomas Raskin, 25, graduated from Amherst College in 2017. Amherst College 220 South Pleasant Street Amherst, MA 01002. He passionately loved his family, friends, and animals, and was devoted to the cause of the global poor,” the statement reads. This is a personal homepage that has not been modified yet. His brilliance and compassion knew no bounds. Thomas Bloom Raskin, 25, was a graduate of Amherst. Jamin Ben “Jamie” Raskin ’83 (D-Md.), announced in a statement Thursday. Jamie Raskin (D-Md.) announced on Thursday night that his son Thomas has died, according to a statement released by his office. Jamie Raskin (D-Md.) revealed the death of his 25-year-old juvenile in an attestation Thursday night, saying his family was squashed by the trouble. “Tommy” Raskin has died, his father, Rep. Thomas Bloom Raskin Cause of Death Dead: Rep. Second year Harvard Law School student Thomas B. 7/1/2023 0 Comments Phpstorm studentIn files where it’s enabled, nearly 40% of code is being written by GitHub Copilot in popular coding languages, like Python-and we expect that to increase. With more than 1.2 million developers in our technical preview over the last 12 months, people who started using GitHub Copilot quickly told us it became an indispensable part of their daily workflows. Code confidently in unfamiliar territory: Code in new languages or try something new, and let GitHub Copilot suggest syntax and code in dozens of languages-so you can spend more time learning by doing.Use your preferred environment: Integrate GitHub Copilot with popular editors, including Neovim, JetBrains IDEs, Visual Studio, and Visual Studio Code as an unobtrusive extension.Get AI-based coding suggestions: Get code suggestions that match a project’s context and style conventions, and cycle through different options to decide what to accept, reject, or edit.GitHub Copilot can suggest complete methods, boilerplate code, whole unit tests, and even complex algorithms. But it’s not only a single word or line of code. When you type code or comments, GitHub Copilot suggests the next line of code. GitHub Copilot distills the collective knowledge of the world’s developers into an editor extension that suggests code in real time, to help you stay focused on what matters most: building great software. We specifically designed GitHub Copilot as an editor extension to make sure nothing gets in the way of what you’re doing. It’s free to use for verified students and maintainers of popular open source software. Just like the rise of compilers and open source, we believe AI-assisted coding will fundamentally change the nature of software development, giving developers a new tool to write code easier and faster so they can be happier in their lives.ĭo you want to start using GitHub Copilot today? Get started with a free trial, and check out our pricing plans. With GitHub Copilot, for the first time in the history of software, AI can be broadly harnessed by developers to write and complete code. Today, I am thrilled to announce that we are making GitHub Copilot generally available to individual developers. But until now, AI has stopped short of improving code, leaving the process of developing software almost completely manual. It’s helping us write emails and essays, automatically generate photo albums of our loved ones, and even acts as a digital assistant to help us order groceries. Since the launch of GitHub Copilot technical preview last year, it’s become abundantly clear that AI is one of the best tools to empower the next generation of developers.Īlready, AI is acting as a copilot in our daily lives. At GitHub, it’s part of our mission to build technology that makes developers happy. 7/1/2023 0 Comments Realtime cryptocurrency tickerOnce the block is filled with data, it is chained to the previous block, which then chains the data in a chronological order. As new data comes in, it is entered in a fresh block. Unlike a typical digital database, blockchain stores data in blocks that are then chained together. Virtually anything of value can be tracked and traded on a blockchain network, reducing the risk and cutting costs for all involved. Their mining is painstaking, costly and only sporadically rewarding.īlockchain is a shared, immutable ledger that facilitates the process of recording transactions and tracking assets in a business network. Cryptocurrencies are digitally mined, where very sophisticated computers solve extremely complex computational mathematics problems. They carry a pre-determined store value of their own, just like any other fiat currency like the US dollar or the Indian rupee. They are tokens that can be used as a form of payment in exchange for online goods and services. However, they are often criticised for the possibility of misuse in illegal activities, exchange rate volatility and the vulnerability of the infrastructure underlying them.Ĭryptocurrencies work using a technology called blockchain. Plus, the digital structure facilitates free portability across geographical borders, divisibility and transparency. Because cryptocurrencies do not have an underlying economic base, they are inflation-proof. Such currencies, theoretically, are immune to government interference or any kind of manipulation. They are built on the blockchain network technology, which ensures transparency and helps track every transaction. Cryptocurrencies are decentralised, meaning that no authority regulates them. They have their own store values, and are designed to use as a medium of exchange for buying goods or services. Cryptocurrency is a digital or virtual coin secured by cryptography, which makes it next to impossible to counterfeit. The big difference is, here there is no owner-issuer and it would, at least in theory, be accepted globally. If you want to give the housing some extra protection, you can wrap the seam in a piece of black electrical tape like we did.Ever received a paper token from your next-door paan shop in lieu of a small change, which he would accept the next time you visit him? Imagine that token digitally, and that's your cryptocurrency. These bolts will attach to the nuts that you placed in the previous step. The back piece of the housing was screwed on with 4 3mm bolts. We made sure not to loosen any wires connected to the Raspberry Pi. Then, the housing was then carefully snapped together. These nuts will be used to hold the housing together. the third front housing piece has to be screwed on after the display has been slotted in.Īfter connecting the display to the Pi, we add 3mm nuts to the 4 extensions on each side of the top piece. The right side has a wider frame portion so that the wires can wrap around to the Raspberry Pi. The combined display unit was slotted into the front piece of the housing. A pair of tweezers made it easy to hold the small hardware in place. The housing parts have small tabs on the sides that allow you to screw them together with small 2.5mm nuts/bolts. The back has 4 counterbored holes so that the screws can sit flush. The Raspberry Pi Zero W was slotted into the middle, back piece with 4 2.5mm nuts/bolts. This step is less critical if you plan on gluing the parts together. A box cutter helped deburr the pieces so that they fit together better. Our print bed was too small to print the entire front/back so we cut them into three pieces on the back side and four pieces on the front. To make the housing, we 3D printed a few PLA parts. My bad.Īre you guys convinced or should I continue adding more pick up lines? Just kidding. Now you should study a little bit about the cars before approaching. The obsession with cars also chases them in their dreams. You’ve got something on your face, let me get it for you. By Melinda Davis JDating Want best Car Pick Up Lines to impress your male or female car obsessed Crush Clean car guy & girls funny, cheesy, corny, dirty wash pickup ultimate collection. I always thought love story starts with ‘L’ but mine started with ‘U’Ģ1. Dress up like a gentleman on your first date.Ģ0. Not 100% but this is the best deal we can get you. Do you like sales? ‘Coz I’m offering 100% discount on me Are you using a photo editing app? ‘Coz every time I look at you, everything else blurs outġ9. Just a little something to support your words.ġ8. Girl, are you an omelette? ‘Coz every time I see you I get 'Eggcited' You know what will suit you the best? My surnameġ7. Have you seen my girlfriend? Oh no, wait. I am no criminal but would you mind keeping an eye on me?ġ5. Take this baby along, if she actually likes dates.ġ4. Which sweetener would you prefer? Sugar, honey or DATES… with me I don’t want you to fly back to heaven without meġ3. Yours doesn’t have to be expensive but chocolate would make a nice return gift. You spoil me with expensive gifts every time we meet-butterflies and a smile Do you have an extra parachute? ‘Coz I’m falling for youġ1. So other than being my walking-talking mood booster, what do you do?ġ0. I was trying to send you something cute, but I don’t think I can fit in this text boxĩ. On that note, dropping a reminder that you actually do need some sunscreen daily.Ĩ. Girl, are you SPF? ‘Coz I need you every day Just increasing her chances of saying yes with a hot pair of sunglasses.Ħ. Do you know (your friend’s name)? He wanted to know if you think I’m hot So be a gentleman, be respectful but don’t hold back when it’s time to flaunt your wiser side.ġ. You’re welcome! 21 Best Pick Up Lines To Level Up Your Flirting Game So if you’re all like “yeah, let’s do this” here are the best pick up lines to send or save for later. But hitting your person-to-be up with a clever pickup line may level up your game.īonus: Letting your crush know what’s up via a tasteful pick up line right from the beginning will only help her respect your honesty. Your “HOW ARE YOUs” might not get you an immediate response. You only get one chance to send that first text. Would you like to start with the same old “heyyyyyy, how are you?” or a well-prepared, witty pickup line to show her you’re into her? Yes, it is *the* text that will set the tone for the whole conversation. Or you’ve finally found the courage to slide into your crush’s DM and it’s definitely not-not freaking you out. Let’s say you have a match on an online dating app and you really, really like her. Gene regulatory networks contain information about regulatory elements of gene expression. Identifying network modules and their biological functions helps decipher the molecular mechanisms of drug effects, identify new drug targets, predict body response to drugs, and organism behavior 23– 25. Global expression data-based computational approaches can utilize gene interaction information for modeling Protein-Protein Interaction Networks (PPINs) and Gene Regulatory Networks (GRNs). Several network analysis studies of drug-disease associations have been used to predict drug side effects with high accuracy. These networks can help understand how drugs influence the disease at the molecular level and identify the crucial gene sets underlying various drug effects 19– 22. Several such studies rely on network topology analysis to identify the effect of chemotherapy on various cancers. Systems biology and network-based methods are recently used to decipher the molecular mechanisms behind drugs and their possible side effects. Some investigations have even reported cardiotoxic side effects for DXR that their molecular mechanisms remain to be deciphered in detail 18. Nevertheless, little is known about the molecular basis of its effect on cell proliferation, estrogen/estrogen receptor signaling, and cell cycle progression 15– 17. The response rates to DXR in patients exposed to DXR for the first time is reported to be 48%, and for more than once is 28% 14. DXR is among the chemotherapy drugs approved to treat ER+breast cancer. DXR induces Reactive Oxygen Species release (ROS) that ROS lead to DNA damage, lipid peroxidation and membrane damage, and apoptotic cell death pathways 13. This drug is used to treat several cancers, including breast, gastric, lung, ovarian, thyroid, sarcoma, non-Hodgkins and Hodgkins lymphoma, multiple myelo-ma, and pediatric cancers 11, 12. Several studies have shown an adverse effect of ER signaling on motility and invasion of cells 6, 7, while a few studies suggested a positive effect of ER signaling on motility and invasion 8, 9.ĭoxorubicin (DXR) is an anthracycline and chemotherapeutic drug isolated from Streptomyces peucetius 10. In clinical diagnosis, 75% of breast tumors are ER+ 5 however, the role of ER signaling in metastasis of breast cancer remains poorly understood. The ER receptor is one of the therapeutic targets for ER+ breast cancer 4. The dysregulation of the Estrogen Receptor (ER) is attributed to two-thirds of all breast cancers. The estrogen hormone and its receptor play essential roles in breast cancer progression. Breast cancer is often curable early, but the metastatic form is almost mortal due to therapeutic resistance 3. The characterization influence biologically-directed therapies and treatment de-escalation 2. This cancer is a heterogeneous disease at the molecular level. Four subtypes of this cancer include luminal A and luminal B, basal-like, and Human Epidermal growth factor Receptor 2 (HER2)-enriched (without ER expression). Breast cancer is the most common cause of cancer and mortality caused by cancers in women worldwide 1. |